Inhibitors | Comment | Organism | Structure |
---|---|---|---|
c-Jun N-terminal protein kinase | incubation with catalytically active JNK leads to significant inhibition of ALDH2 activity. CCl4 exposure activates JNK which translocates to mitochondria and phosphorylates ALDH2 contributing to inhibition of ALDH2 activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | isoform ALDH2 | Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P11884 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CCl4 exposure activates JNK, which translocates to mitochondria and phosphorylates ALDH2 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
propionaldehyde + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH2 | isoform | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of ALDH2 leads to accumulation of cytotoxic 4-hydroxynonenal and malondialdehyde, which can cause cell death through activation of c-Jun N-terminal protein kinase and/or p38 kinase | Rattus norvegicus |